Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 9/20 | 0.43 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136199 | 0.86 | MMP12 (0.44) | ADAM17MMP13 | |
| SCHEMBL5887400 | 0.85 | ADAM17 (0.46) | ADAM17MMP13MMP2 | |
| SCHEMBL5887792 | 0.85 | ADAM17 (0.42) | ADAM17MMP13 | |
| Trifluoroacetic Acid SCHEMBL6136039 | 0.82 | ADAM17 (0.48) | ADAM17MMP13MMP2 | |
| SCHEMBL5887843 | 0.80 | ADAM17 (0.43) | ADAM17MMP13MMP2 | |
| SCHEMBL5887576 | 0.78 | ADAM17 (0.50) | ADAM17MMP13MMP2 | |
| SCHEMBL5887640 | 0.76 | ADAM17 (0.46) | ADAM17MMP13MMP2 | |
| SCHEMBL6099593 | 0.74 | ADAM17 (0.46) | ADAM17MMP13MMP2 | |
| SCHEMBL5035186 | 0.72 | ADAM17 (0.45) | ADAM17MMP13MMP2 | |
| SCHEMBL5035414 | 0.72 | ADAM17 (0.43) | ADAM17MMP13MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1546109-A4 | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME (TACE) | BRISTOL MYERS SQUIBB CO (US) | 2005-11-09 | — | — | EP | disclosed |
| EP-1546109-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME (TACE) | Bristol-Myers Squibb Company (US) | 2005-06-29 | — | — | EP | disclosed |
| WO-2004033632-A2 | HYDANTOIN DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-ALPHA CONVERTING ENZYME (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-04-22 | — | — | WO | disclosed |