Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | SHMT2 | P34897 | 4/20 | 0.50 |
| ▸ | PPARG | P37231 | 3/20 | 0.50 |
| ▸ | PPARA | Q07869 | 3/20 | 0.50 |
| ▸ | SHMT1 | P34896 | 2/20 | 0.50 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.48 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6136460 | 1.00 | LMNA (0.56) | LMNAGAATSHRKMT2ASHMT2 | |
| SCHEMBL6136446 | 0.86 | LMNA (0.50) | LMNAGAATSHRKMT2ASHMT2 | |
| SCHEMBL6136445 | 0.86 | LMNA (0.50) | LMNAGAATSHRKMT2ASHMT2 | |
| SCHEMBL24663712 | 0.80 | LMNA (0.52) | LMNAGAATSHRKMT2APPARG | |
| SCHEMBL4415483 | 0.77 | LMNA (0.58) | LMNAGAATSHRKMT2AFFAR1 | |
| Hydrochloric Acid SCHEMBL1374005 | 0.76 | LMNA (0.57) | LMNAGAATSHRKMT2AFFAR1 | |
| SCHEMBL20255810 | 0.74 | SHMT2 (0.79) | LMNAGAAKMT2ASHMT2SHMT1 | |
| SCHEMBL6932791 | 0.72 | PPARG (0.46) | LMNAGAATSHRKMT2APPARG | |
| SCHEMBL5869970 | 0.72 | PPARG (0.46) | LMNAGAATSHRKMT2APPARG | |
| SCHEMBL5869966 | 0.72 | PPARG (0.46) | LMNAGAATSHRKMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0951464-B1 | N-(ARYL/HETEROARYLACETYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2005-05-11 | — | — | EP | claimed |