Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 8/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.42 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.33 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6105265 | 0.83 | CXCR2 (0.67) | CXCR2CXCR1IDO1SRCDHODH | |
| SCHEMBL5595003 | 0.77 | CXCR2 (0.66) | CXCR2CXCR1MEN1KMT2AKDM4E | |
| SCHEMBL6129952 | 0.76 | CXCR2 (0.45) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7063167 | 0.74 | CXCR2 (0.46) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7063170 | 0.74 | CXCR2 (0.46) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6931689 | 0.73 | CXCR2 (0.42) | CXCR2CXCR1SRCTAS1R3TAS1R1 | |
| SCHEMBL6104139 | 0.72 | CXCR2 (0.74) | CXCR2CXCR1IDO1KMT2AKDM4E | |
| SCHEMBL7489083 | 0.69 | CXCR2 (0.69) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7514963 | 0.69 | CXCR2 (0.73) | CXCR2CXCR1MEN1KMT2AKDM4E | |
| SCHEMBL13587230 | 0.69 | NPC1 (0.40) | CXCR2IDO1SRCDHODHALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1284956-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-08-24 | — | — | EP | claimed |
| JP-2004509070-A | — | — | 2004-03-25 | — | — | JP | claimed |
| EP-1284956-A1 | IL-8 RECEPTOR ANTAGONISTS | Smithkline Beecham (US) | 2003-02-26 | — | — | EP | claimed |
| WO-2001092202-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-12-06 | — | — | WO | claimed |