Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.69 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.69 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.58 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5595077 | 0.90 | CXCR2 (0.85) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL5595003 | 0.89 | CXCR2 (0.66) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL7496226 | 0.84 | CXCR2 (0.77) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL7489930 | 0.83 | CXCR2 (1.00) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL7514963 | 0.81 | CXCR2 (0.73) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL5594865 | 0.78 | CXCR2 (0.71) | CXCR2CXCR1MEN1KMT2AHPGD | |
| SCHEMBL3709514 | 0.78 | CXCR2 (0.71) | CXCR2CXCR1MEN1KMT2AHPGD | |
| SCHEMBL5595159 | 0.77 | CXCR2 (0.62) | CXCR2CXCR1MEN1KMT2AMAPT | |
| SCHEMBL5595100 | 0.77 | MEN1 (0.61) | CXCR2MEN1KMT2AMAPTLMNA | |
| SCHEMBL7063167 | 0.76 | CXCR2 (0.46) | CXCR2CXCR1MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0896531-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-30 | — | — | EP | disclosed |
| EP-0896531-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-02-17 | — | — | EP | disclosed |
| WO-1997029743-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-08-21 | — | — | WO | disclosed |