Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 7/20 | 0.53 |
| ▸ | TAS1R1 | Q7RTX1 | 7/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6329414 | 0.86 | TAS1R3 (0.53) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL12780432 | 0.86 | MEN1 (0.59) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL4713028 | 0.86 | TSHR (0.63) | PDE4DMAPTKMT2AMEN1SMN1; SMN2 | |
| SCHEMBL2166529 | 0.85 | GSK3B (0.54) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL22570710 | 0.85 | TAS1R3 (0.51) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL29620782 | 0.85 | GSK3B (0.54) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL9155650 | 0.85 | PDE4D (0.54) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL22570670 | 0.84 | TAS1R3 (0.49) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| Hydrochloric Acid SCHEMBL29393777 | 0.83 | TAS1R3 (0.50) | TAS1R3TAS1R1PDE4DMAPTPOLB | |
| SCHEMBL3950960 | 0.83 | TAS1R3 (0.57) | TAS1R3TAS1R1PDE4DMAPTPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111004107-B | Substituted dichlorobenzene compound containing propenone, preparation method and application | 山东大学 | 2021-03-16 | — | — | CN | disclosed |
| CN-111004107-A | Substituted dichlorobenzene compound containing propenone, preparation method and application | 山东大学 | 2020-04-14 | — | — | CN | disclosed |
| EP-1011651-B1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2005-04-27 | — | — | EP | disclosed |
| EP-1011651-A4 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO INC (US) | 2000-06-28 | — | — | EP | disclosed |
| EP-1011651-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | Merck & Co., Inc. (US) | 2000-06-28 | — | — | EP | disclosed |
| US-6020382-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 2000-02-01 | — | — | US | disclosed |
| US-5847008-A | Method of treating diabetes and related disease states | MERCK & CO., INC. (US) | 1998-12-08 | — | — | US | disclosed |
| WO-1997027847-A1 | METHOD OF TREATING DIABETES AND RELATED DISEASE STATES | MERCK & CO., INC. (US) | 1997-08-07 | — | — | WO | disclosed |
| US-5466717-A | INHIBITING THE GROWTH OF MICROORGANISMS IN AN AQUEOUS SYSTEM | BUCKMAN LABORATORIES INT'L, INC. (US) | 1995-11-14 | — | — | US | disclosed |
| EP-0639049-A1 | HALOGENATED 4'-METHOXYACETOPHENONES AS MICROBICIDES AND PRESERVATIVES | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 1995-02-22 | — | — | EP | disclosed |
| WO-1993022918-A1 | HALOGENATED 4'-METHOXYACETOPHENONES AS MICROBICIDES AND PRESERVATIVES | BUCKMAN LABORATORIES INTERNATIONAL, INC. (US) | 1993-11-25 | — | — | WO | disclosed |
| EP-0106565-B1 | LEUKOTRIENE ANTAGONISTS, THEIR PRODUCTION, AND COMPOSITIONS CONTAINING THEM | MERCK FROSST CANADA INC. (CA) | 1986-09-10 | — | — | EP | disclosed |
| EP-0106565-A1 | Leukotriene antagonists, their production, and compositions containing them | MERCK FROSST CANADA INC. (CA) | 1984-04-25 | — | — | EP | disclosed |