SCHEMBL6137331

SCHEMBL6137331

CC1=C(C#N)C(c2cccc(C(F)(F)F)c2)NC(=O)N1C(=O)O

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ELANE P08246 8/20 0.57
CYP2C9 P11712 6/20 0.57
LMNA P02545 4/20 0.52
SMN1; SMN2 Q16637 3/20 0.52
MAPT P10636 2/20 0.52
HTT P42858 1/20 0.52
RECQL P46063 1/20 0.48
ALDH1A1 P00352 1/20 0.46
GUSB P08236 1/20 0.46
ADRB1 P08588 1/20 0.46
HTR1A P08908 1/20 0.46
HRH3 Q9Y5N1 1/20 0.46
CYP3A4 P08684 1/20 0.45
CYP2C8 P10632 1/20 0.44
CYP2C19 P33261 1/20 0.44
PKM P14618 1/20 0.44
KMT2A Q03164 2/20 0.44
POLB P06746 1/20 0.44
MEN1 O00255 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6137082 0.85 TDP1 (0.50) ELANECYP2C9LMNAMAPTRECQL
SCHEMBL6609236 0.84 ELANE (0.45) ELANECYP2C9
SCHEMBL6137166 0.84 KMT2A (0.45) ELANECYP2C9LMNASMN1; SMN2HTT
SCHEMBL6137118 0.83 HTT (0.43) ELANECYP2C9LMNASMN1; SMN2MAPT
SCHEMBL6608283 0.83 ELANE (0.40) ELANECYP2C9LMNAMAPTRECQL
SCHEMBL6137365 0.83 ELANE (0.40) ELANECYP2C9LMNASMN1; SMN2MAPT
SCHEMBL6608090 0.83 MAPK1 (0.44) ELANECYP2C9LMNASMN1; SMN2MAPT
SCHEMBL6609319 0.81 ALDH1A1 (0.46) ELANECYP2C9MAPTALDH1A1
SCHEMBL6137233 0.81 ELANE (0.39) ELANECYP2C9LMNASMN1; SMN2MAPT
SCHEMBL6137183 0.80 ATM (0.50) LMNASMN1; SMN2MAPTHTTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1373221-A4 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL MYERS SQUIBB CO (US) 2004-09-29 EP claimed
EP-1373221-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES Bristol-Myers Squibb Company (US) 2004-01-02 EP claimed
WO-2002079149-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO claimed
EP-1372657-A4 A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS BRISTOL MYERS SQUIBB CO (US) 2005-11-09 EP disclosed
EP-1373223-A4 CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL MYERS SQUIBB CO (US) 2004-09-29 EP disclosed
EP-1373221-A4 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL MYERS SQUIBB CO (US) 2004-09-29 EP disclosed
EP-1372657-A2 A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS Bristol-Myers Squibb Company (US) 2004-01-02 EP disclosed
EP-1373223-A1 CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES Bristol-Myers Squibb Company (US) 2004-01-02 EP disclosed
EP-1373221-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES Bristol-Myers Squibb Company (US) 2004-01-02 EP disclosed
WO-2002079169-A1 CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO disclosed
WO-2002079149-A2 NOVEL CYANO-SUBSTITUTED DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USE TO TREAT DISEASES BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO disclosed
WO-2002078639-A2 A METHOD OF TREATING PROLIFERATIVE DISEASES USING EG5 INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2002-10-10 WO disclosed