Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.47 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | STAT3 | P40763 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.36 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.36 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137803 | 0.83 | ALDH1A1 (0.39) | BCHEKMT2AALDH1A1RAB9ALMNA | |
| SCHEMBL6137318 | 0.83 | CDK1 (0.42) | BCHEKMT2ACDK1ALDH1A1UCHL1 | |
| SCHEMBL6137336 | 0.81 | GPR119 (0.37) | BCHEGPR119KMT2ALMNADDB1 | |
| SCHEMBL26628082 | 0.80 | BCHE (0.52) | BCHEGPR119CDK1KDM1ASTS | |
| SCHEMBL31274704 | 0.80 | BCHE (0.52) | BCHEGPR119CDK1KDM1ASTS | |
| SCHEMBL30828978 | 0.79 | BCHE (0.51) | BCHEGPR119KMT2ACDK1KDM1A | |
| SCHEMBL6137764 | 0.79 | GPR119 (0.45) | GPR119KMT2AALDH1A1CYP2C19KDM4E | |
| SCHEMBL23959036 | 0.76 | BCHE (0.49) | BCHEGPR119KMT2ACDK1ALDH1A1 | |
| SCHEMBL28695974 | 0.76 | BCHE (0.49) | BCHEGPR119KMT2ACDK1KDM1A | |
| SCHEMBL18025768 | 0.76 | BCHE (0.49) | BCHEGPR119CDK1KDM1ASTS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1129077-B9 | FLUORINATED 3,4-DIHYDROQUINOLINE DERIVATIVES USED AS NOS INHIBITORS | SCHERING AG (DE) | 2005-07-20 | — | — | EP | disclosed |
| EP-1129077-B1 | FLUORINATED 3,4-DIHYDROQUINOLINE DERIVATIVES USED AS NOS INHIBITORS | SCHERING AG (DE) | 2005-04-20 | — | — | EP | disclosed |
| US-6579883-B1 | Nitrogen monoxide synthases; 4-amino-8-bromo-3a-fluoro-2,3,3a,9b-tetrahydro-1H-cyclopenta (c) quinoline; neurodegenerative, autoimmune, cardiovascular diseases | SCHERING AKTIENGESELLSCHAFT (DE) | 2003-06-17 | — | — | US | disclosed |