Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | HRH1 | P35367 | 2/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6138577 | 0.98 | CHRNA7 (0.46) | CHRNA7TDP1L3MBTL1CYP2A6CYP1A2 | |
| SCHEMBL6138220 | 0.75 | CHRNA7 (0.57) | CHRNA7TDP1L3MBTL1CYP2A6HRH1 | |
| Hydrochloric Acid SCHEMBL6138304 | 0.74 | CHRNA7 (0.56) | CHRNA7TDP1L3MBTL1CYP2A6HRH1 | |
| SCHEMBL6138243 | 0.74 | CHRNB2 (0.59) | CHRNB2CHRNA4 | |
| SCHEMBL6138217 | 0.73 | CHRNB2 (0.57) | CHRNB2CHRNA4 | |
| SCHEMBL173147 | 0.73 | — | — | |
| SCHEMBL30672504 | 0.73 | — | — | |
| SCHEMBL29485692 | 0.72 | CHRNA7 (0.74) | CHRNA7TDP1L3MBTL1CYP2A6CYP1A2 | |
| SCHEMBL724866 | 0.72 | CHRNA7 (0.74) | CHRNA7TDP1L3MBTL1CYP2A6CYP1A2 | |
| SCHEMBL29403584 | 0.72 | ATM (0.57) | CHRNA7TDP1L3MBTL1CYP2A6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | claimed |
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | claimed |
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | disclosed |
| EP-1170281-A1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | LES LABORATOIRES SERVIER (FR) | 2002-01-09 | — | — | EP | disclosed |