SCHEMBL6138261

SCHEMBL6138261

COCOc1ccc(C=Cc2ccc(CC=C(C)C)c(OC(OC)OC)c2)cc1CC=C(C)C

nearest known ligand 0.43

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
AKR1C3 P42330 14/20 0.43
AKR1C2 P52895 14/20 0.43
PTGS2 P35354 2/20 0.43
PTGS1 P23219 1/20 0.43
CYP19A1 P11511 5/20 0.41
AKR1C4 P17516 1/20 0.39
ALOX5 P09917 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4268956 0.87 PTGS2 (0.41) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL4267496 0.82 PTGS2 (0.50) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL4267499 0.82 PTGS2 (0.50) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL3672848 0.79 TUBB4A (0.47) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL3303998 0.77 CYP19A1 (0.49) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL3670644 0.77 PTGS2 (0.51) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL6137889 0.75 PTGS2 (0.51) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL14162488 0.71 CYP19A1 (0.42) AKR1C3AKR1C2CYP19A1
SCHEMBL4259691 0.70 AKR1C3 (0.40) AKR1C3AKR1C2PTGS2PTGS1CYP19A1
SCHEMBL3299183 0.70 CYP19A1 (0.71) CYP19A1ALOX5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1435894-A4 CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS, AND METHODS GALILEO PHARMACEUTICALS INC (US) 2005-07-06 EP disclosed
EP-1435894-A2 CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS, AND METHODS Galileo Pharmaceuticals, Inc. (US) 2004-07-14 EP disclosed
WO-2003009807-A2 CYTOPROTECTIVE COMPOUNDS, PHARMACEUTICAL AND COSMETIC FORMULATIONS, AND METHODS GALILEO LABORATORIES, INC. (US) 2003-02-06 WO disclosed