Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACLY | P53396 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 11/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.41 |
| ▸ | CCR6 | P51684 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138814 | 0.85 | CCR6 (0.48) | CXCR2ALDH1A1CCR6MAPTSMN1; SMN2 | |
| SCHEMBL6138738 | 0.82 | CXCR2 (0.54) | CXCR2CCR6 | |
| SCHEMBL5711768 | 0.82 | CXCR2 (0.48) | ACLYCXCR2CCR6 | |
| SCHEMBL6138890 | 0.81 | CXCR2 (0.66) | CXCR2 | |
| SCHEMBL6138817 | 0.79 | CXCR2 (0.61) | CXCR2CCR6 | |
| SCHEMBL6103699 | 0.78 | CXCR2 (0.62) | ACLYCXCR2GAATSHRLMNA | |
| SCHEMBL6138369 | 0.75 | CXCR2 (0.47) | CXCR2CCR6 | |
| SCHEMBL6138767 | 0.74 | CXCR2 (0.50) | CXCR2CCR6 | |
| SCHEMBL3882244 | 0.68 | CXCR2 (0.69) | CXCR2ALDH1A1CCR6MAPTSMN1; SMN2 | |
| SCHEMBL5711770 | 0.68 | CCR6 (0.56) | CXCR2CCR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351933-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1351933-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057230-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-25 | — | — | WO | disclosed |