Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 19/20 | 0.61 |
| ▸ | CXCR1 | P25024 | 5/20 | 0.46 |
| ▸ | CCR6 | P51684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138738 | 0.87 | CXCR2 (0.54) | CXCR2CCR6 | |
| SCHEMBL6138890 | 0.83 | CXCR2 (0.66) | CXCR2 | |
| SCHEMBL5711800 | 0.81 | CXCR2 (0.66) | CXCR2CXCR1CCR6 | |
| SCHEMBL3880212 | 0.81 | CXCR2 (0.73) | CXCR2CXCR1CCR6 | |
| SCHEMBL6138814 | 0.81 | CCR6 (0.48) | CXCR2CCR6 | |
| SCHEMBL6138369 | 0.80 | CXCR2 (0.47) | CXCR2CCR6 | |
| SCHEMBL6138330 | 0.79 | ACLY (0.46) | CXCR2CCR6 | |
| SCHEMBL6138767 | 0.76 | CXCR2 (0.50) | CXCR2CCR6 | |
| SCHEMBL6243497 | 0.75 | CXCR2 (1.00) | CXCR2CXCR1 | |
| SCHEMBL6104523 | 0.75 | CXCR2 (1.00) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351933-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-07 | — | — | EP | claimed |
| EP-1351933-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-10-15 | — | — | EP | claimed |
| WO-2002057230-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-25 | — | — | WO | claimed |
| EP-1351933-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1351933-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057230-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-25 | — | — | WO | disclosed |