Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR6 | P51684 | 4/20 | 0.48 |
| ▸ | CXCR2 | P25025 | 8/20 | 0.44 |
| ▸ | CLCN2 | P51788 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138330 | 0.85 | ACLY (0.46) | CCR6CXCR2ALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6138738 | 0.84 | CXCR2 (0.54) | CCR6CXCR2 | |
| SCHEMBL3882244 | 0.82 | CXCR2 (0.69) | CCR6CXCR2CLCN2ALDH1A1MAPK1 | |
| SCHEMBL5711770 | 0.81 | CCR6 (0.56) | CCR6CXCR2 | |
| SCHEMBL6138817 | 0.81 | CXCR2 (0.61) | CCR6CXCR2 | |
| SCHEMBL6138890 | 0.80 | CXCR2 (0.66) | CXCR2 | |
| SCHEMBL6104443 | 0.77 | CXCR2 (0.61) | CXCR2ALDH1A1MAPK1MAPTKDM4E | |
| SCHEMBL6138369 | 0.77 | CXCR2 (0.47) | CCR6CXCR2 | |
| SCHEMBL6138767 | 0.75 | CXCR2 (0.50) | CCR6CXCR2 | |
| SCHEMBL5711805 | 0.75 | CXCR2 (0.74) | CCR6CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1351933-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-09-07 | — | — | EP | disclosed |
| EP-1351933-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2003-10-15 | — | — | EP | disclosed |
| WO-2002057230-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-07-25 | — | — | WO | disclosed |