Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.47 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.46 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.46 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6138228 | 0.85 | CHRNB2 (0.53) | CHRNB2CHRNA4 | |
| SCHEMBL4643117 | 0.79 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| SCHEMBL4643121 | 0.79 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| SCHEMBL4643126 | 0.79 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| SCHEMBL6138305 | 0.79 | CHRNB2 (0.49) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL5118971 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL5118970 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL5118968 | 0.78 | CHRNB2 (0.50) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| Hydrochloric Acid SCHEMBL6138572 | 0.78 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 | |
| SCHEMBL4642653 | 0.77 | CHRNB2 (0.51) | CHRNB2CHRNA4CHRNA1CHRNB1CHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1170281-B1 | 1,1- and 1,2-disubstituted cyclopropanes, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2005-12-21 | — | — | EP | claimed |