Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.44 |
| ▸ | LTA4H | P09960 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.36 |
| ▸ | RARB | P10826 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.34 |
| ▸ | PPARG | P37231 | 2/20 | 0.34 |
| ▸ | PTGES | O14684 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RXRA | P19793 | 1/20 | 0.33 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.33 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.33 |
| ▸ | PPARA | Q07869 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3598408 | 0.87 | LTA4H (0.44) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL3598346 | 0.87 | LTA4H (0.44) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL3598347 | 0.87 | LTA4H (0.44) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL3593691 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL6138195 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL3593694 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL3595599 | 0.82 | LTA4H (0.42) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL3595602 | 0.82 | LTA4H (0.42) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL3595606 | 0.82 | LTA4H (0.42) | PDE4APDE4BPDE4CPDE4DLTA4H | |
| SCHEMBL6138471 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1216223-B1 | NOVEL DICARBOXYLIC ACID DERIVATIVES WITH PHARMACEUTICAL PROPERTIES | BAYER HEALTHCARE AG (DE) | 2005-11-09 | — | — | EP | disclosed |
| EP-1216223-A1 | NOVEL DICARBOXYLIC ACID DERIVATIVES WITH PHARMACEUTICAL PROPERTIES | Bayer Aktiengesellschaft (DE) | 2002-06-26 | — | — | EP | disclosed |
| WO-2001019778-A1 | NOVEL DICARBOXYLIC ACID DERIVATIVES WITH PHARMACEUTICAL PROPERTIES | BAYER AKTIENGESELLSCHAFT (DE) | 2001-03-22 | — | — | WO | disclosed |