Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 6/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23920040 | 0.86 | AKR1C1 (0.58) | AKR1C1HDAC4ALDH1A1ALOX15MEN1 | |
| SCHEMBL23920039 | 0.84 | AKR1C1 (0.60) | AKR1C1HDAC4ALDH1A1ALOX15MEN1 | |
| SCHEMBL31189199 | 0.80 | AKR1C1 (0.55) | AKR1C1HDAC4ALDH1A1ALOX15MEN1 | |
| SCHEMBL2565642 | 0.80 | ALDH1A1 (0.48) | AKR1C1HDAC4ALDH1A1ALOX15MEN1 | |
| SCHEMBL22745669 | 0.80 | AKR1C1 (0.55) | AKR1C1HDAC4ALDH1A1ALOX15MEN1 | |
| SCHEMBL19335085 | 0.78 | AKR1C1 (0.68) | AKR1C1HDAC4ALDH1A1MEN1KMT2A | |
| SCHEMBL19249604 | 0.78 | AKR1C1 (0.68) | AKR1C1HDAC4ALDH1A1MEN1KMT2A | |
| SCHEMBL1061631 | 0.78 | AKR1C1 (0.68) | AKR1C1HDAC4ALDH1A1MEN1KMT2A | |
| SCHEMBL19335064 | 0.78 | AKR1C1 (0.68) | AKR1C1HDAC4ALDH1A1MEN1KMT2A | |
| SCHEMBL4805485 | 0.77 | HDAC4 (0.63) | AKR1C1HDAC4ALDH1A1ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1583736-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS | TopoTarget UK Limited (GB) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004065354-A1 | CARBAMIC ACID COMPOUNDS COMPRISING AN ESTER OR KETONE LINKAGE AS HDAC INHIBITORS | TOPOTARGET UK LIMITED (GB) | 2004-08-05 | — | — | WO | disclosed |