Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 14/20 | 0.35 |
| ▸ | CASP7 | P55210 | 12/20 | 0.35 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | CASP9 | P55211 | 1/20 | 0.33 |
| ▸ | CUL4A | Q13619 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.33 |
| ▸ | CDC42BPB | Q9Y5S2 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6562116 | 0.74 | ALDH1A1 (0.48) | — | |
| SCHEMBL9899670 | 0.74 | MAPT (0.54) | CASP3CASP7DRD2ADORA2AADORA1 | |
| SCHEMBL9899672 | 0.74 | MAPT (0.54) | CASP3CASP7DRD2ADORA2AADORA1 | |
| SCHEMBL2770881 | 0.70 | ALDH1A1 (0.34) | — | |
| SCHEMBL8075591 | 0.68 | MAPT (0.48) | ADORA2AADORA1 | |
| SCHEMBL6565980 | 0.67 | HSP90AA1 (0.39) | — | |
| SCHEMBL9900174 | 0.67 | MAPT (0.34) | CASP3CASP7DRD2ROCK2ROCK1 | |
| SCHEMBL9900175 | 0.67 | MAPT (0.34) | CASP3CASP7DRD2ROCK2ROCK1 | |
| SCHEMBL18110567 | 0.67 | CHRNB4 (0.42) | CASP3CASP7ROCK2ROCK1CDC42BPB | |
| SCHEMBL18110569 | 0.67 | CHRNB4 (0.42) | CASP3CASP7ROCK2ROCK1CDC42BPB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272175-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1272175-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001072960-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | WO | disclosed |