SCHEMBL6139322

SCHEMBL6139322

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nearest known ligand 0.46

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.46
LMNA P02545 3/20 0.46
HPGD P15428 2/20 0.46
TSHR P16473 2/20 0.46
MAPK1 P28482 1/20 0.46
RECQL P46063 1/20 0.45
TP53 P04637 1/20 0.44
HDAC8 Q9BY41 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
ALDH1A1 P00352 1/20 0.44
POLB P06746 1/20 0.43
PSMB5 P28074 1/20 0.41
CYP2C19 P33261 1/20 0.41
KMT2A Q03164 1/20 0.40
CYP3A4 P08684 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6139318 1.00 SMN1; SMN2 (0.46) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL9829571 0.87 SMN1; SMN2 (0.57) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL7890180 0.87 SMN1; SMN2 (0.57) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL10809127 0.86 TP53 (0.48) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL7899963 0.85 SMN1; SMN2 (0.59) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL9831322 0.85 SMN1; SMN2 (0.59) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL23441779 0.81 TP53 (0.57) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL8829934 0.81 L3MBTL1 (0.56) HPGDTSHRMAPK1RECQLTP53
SCHEMBL7898085 0.81 TSHR (0.56) SMN1; SMN2LMNAHPGDTSHRMAPK1
SCHEMBL9829897 0.81 L3MBTL1 (0.56) HPGDTSHRMAPK1RECQLTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1047391-A4 ALPHA-AMIDES OF L-AMINO ACIDS AS FRAGRANCE PRECURSORS GILLETTE CO (US) 2005-01-19 EP claimed
US-6238655-B1 USEFUL IN THE FORMULATION OF DEODORANTS, ANTIPERSPIRANTS, BODY SPRAYS, AND OTHER SKIN TREATMENT COMPOSITIONS. THE GILLETTE COMPANY 2001-05-29 US claimed
EP-1047391-A1 ALPHA-AMIDES OF L-AMINO ACIDS AS FRAGRANCE PRECURSORS THE GILLETTE COMPANY (US) 2000-11-02 EP claimed
WO-1999030679-A1 α-AMIDES OF L-AMINO ACIDS AS FRAGRANCE PRECURSORS THE GILLETTE COMPANY (US) 1999-06-24 WO claimed
EP-1047391-A4 ALPHA-AMIDES OF L-AMINO ACIDS AS FRAGRANCE PRECURSORS GILLETTE CO (US) 2005-01-19 EP disclosed
US-6238655-B1 USEFUL IN THE FORMULATION OF DEODORANTS, ANTIPERSPIRANTS, BODY SPRAYS, AND OTHER SKIN TREATMENT COMPOSITIONS. THE GILLETTE COMPANY 2001-05-29 US disclosed
EP-1047391-A1 ALPHA-AMIDES OF L-AMINO ACIDS AS FRAGRANCE PRECURSORS THE GILLETTE COMPANY (US) 2000-11-02 EP disclosed
WO-1999030679-A1 α-AMIDES OF L-AMINO ACIDS AS FRAGRANCE PRECURSORS THE GILLETTE COMPANY (US) 1999-06-24 WO disclosed
EP-0226304-B1 COMPOSITION CONTAINING A PENEM OR CARBAPENEM ANTIBIOTIC SANKYO COMPANY LIMITED (JP) 1991-08-28 EP disclosed
US-4757066-A Reduces renal toxicity SANKYO COMPANY LIMITED (JP) 1988-07-12 US disclosed
EP-0226304-A1 Composition containing a penem or carbapenem antibiotic SANKYO COMPANY LIMITED (JP) 1987-06-24 EP disclosed