SCHEMBL6139512

SCHEMBL6139512

CO[Si](CCCc1nc2ccccc2s1)(OC)OC.SSSS

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 2/20 0.49
HTT P42858 2/20 0.49
ALOX15 P16050 1/20 0.49
ALDH1A1 P00352 4/20 0.48
MAPT P10636 3/20 0.48
PKM P14618 3/20 0.48
NPC1 O15118 1/20 0.48
RAB9A P51151 1/20 0.48
POLB P06746 2/20 0.47
MEN1 O00255 1/20 0.47
KMT2A Q03164 1/20 0.47
DRD2 P14416 3/20 0.45
HTR1A P08908 1/20 0.45
SLC6A4 P31645 1/20 0.45
HTR7 P34969 1/20 0.45
LMNA P02545 2/20 0.45
HPGD P15428 2/20 0.44
ATM Q13315 1/20 0.44
DRD4 P21917 2/20 0.44
DRD3 P35462 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6911656 0.93 SMN1; SMN2 (0.55) SMN1; SMN2HTTALOX15ALDH1A1MAPT
Hydrogen Sulfide SCHEMBL467041 0.92 SMN1; SMN2 (0.54) SMN1; SMN2HTTALOX15ALDH1A1MAPT
SCHEMBL6910496 0.81 SMN1; SMN2 (0.54) SMN1; SMN2HTTALOX15ALDH1A1MAPT
SCHEMBL6912456 0.80 SMN1; SMN2 (0.52) SMN1; SMN2HTTALOX15ALDH1A1MAPT
Hydrogen Sulfide SCHEMBL379530 0.78 SMN1; SMN2 (0.51) SMN1; SMN2HTTALOX15ALDH1A1MAPT
Hydrogen Sulfide SCHEMBL29254226 0.78 SMN1; SMN2 (0.51) SMN1; SMN2HTTALOX15ALDH1A1MAPT
SCHEMBL11125440 0.77 HTT (0.59) SMN1; SMN2HTTALOX15ALDH1A1MAPT
SCHEMBL9641726 0.76 SMN1; SMN2 (0.70) SMN1; SMN2HTTALOX15MAPTNPC1
SCHEMBL27509034 0.75 SMN1; SMN2 (0.68) SMN1; SMN2HTTALOX15NPC1RAB9A
SCHEMBL2034241 0.74 SMN1; SMN2 (0.62) SMN1; SMN2HTTALOX15NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1262528-B1 Composite particles, and tread rubber composition, paint and resin compositions using the same TODA KOGYO CORP (JP) 2005-01-05 EP disclosed
US-6800684-B2 PHOTOSTABILITY, DISCOLORATION INHIBITION; CONTROLLING PARTICLE SIZE TODA KOGYO CORPORATION (JP) 2004-10-05 US disclosed
US-20030105213-A1 Composite particles, and tread rubber composition, paint and resin composition using the same TODA KOGYO CORPORATION (JP) 2003-06-05 US disclosed
EP-1262528-A2 Composite particles, and tread rubber composition, paint and resin compositions using the same Toda Kogyo Corporation (JP) 2002-12-04 EP disclosed