Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.39 |
| ▸ | DRD3 | P35462 | 5/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.39 |
| ▸ | DRD1 | P21728 | 3/20 | 0.39 |
| ▸ | DRD5 | P21918 | 3/20 | 0.39 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | OPRL1 | P41146 | 6/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7143580 | 0.79 | DRD2 (0.52) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL6139843 | 0.77 | PPARG (0.46) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2253842 | 0.74 | DGAT1 (0.39) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2253838 | 0.74 | DGAT1 (0.39) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL5536891 | 0.74 | DGAT1 (0.39) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL19859319 | 0.74 | DRD2 (0.44) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL7141341 | 0.72 | SCN9A (0.47) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL19859161 | 0.72 | DRD2 (0.43) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL10214251 | 0.69 | DRD2 (0.42) | DRD2DRD3DRD4DRD1DRD5 | |
| SCHEMBL2910645 | 0.69 | SOS1 (0.51) | DRD2DRD3DRD4HTR1DHSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1196403-B1 | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES | SANOFI AVENTIS (FR) | 2005-11-09 | — | — | EP | disclosed |
| US-6908914-B1 | Antipsychotic cyclic N-aralkylamines | SANOFI-SYNTHELABO (FR) | 2005-06-21 | — | — | US | disclosed |
| EP-1196403-A1 | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES | Sanofi-Aventis (FR) | 2002-04-17 | — | — | EP | disclosed |
| WO-2001002380-A1 | ANTIPSYCHOTIC CYCLIC N-ARALKYL AMINES | SANOFI-SYNTHELABO (FR) | 2001-01-11 | — | — | WO | disclosed |