Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | VEGFA | P15692 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.32 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.31 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | CASP7 | P55210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141269 | 0.90 | VEGFA (0.35) | VEGFAEGLN1CXCR1CXCR2HDAC8 | |
| SCHEMBL6140467 | 0.90 | CXCR2 (0.33) | VEGFAEGLN1CXCR2HDAC8HDAC6 | |
| SCHEMBL6140473 | 0.90 | CXCR2 (0.33) | VEGFAEGLN1CXCR2HDAC8HDAC6 | |
| SCHEMBL27580734 | 0.90 | CXCR2 (0.32) | CXCR1CXCR2 | |
| SCHEMBL6140719 | 0.87 | CASP3 (0.32) | CASP3CASP7 | |
| SCHEMBL6137020 | 0.86 | CASP3 (0.40) | CASP3CASP7 | |
| SCHEMBL6137021 | 0.86 | CASP3 (0.40) | CASP3CASP7 | |
| SCHEMBL2768274 | 0.80 | CXCR2 (0.43) | CXCR1CXCR2 | |
| SCHEMBL2768897 | 0.80 | CXCR2 (0.43) | CXCR1CXCR2 | |
| SCHEMBL2768276 | 0.80 | CXCR2 (0.43) | CXCR1CXCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1272175-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-08-31 | — | — | EP | disclosed |
| EP-1272175-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-01-08 | — | — | EP | disclosed |
| WO-2001072960-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-10-04 | — | — | WO | disclosed |