Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP3 | P42574 | 17/20 | 0.40 |
| ▸ | CASP7 | P55210 | 16/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
| ▸ | CASP9 | P55211 | 1/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6137021 | 1.00 | CASP3 (0.40) | CASP3CASP7CASP1CASP9OPRM1 | |
| SCHEMBL7546977 | 0.93 | CASP3 (0.40) | CASP3CASP7CASP1CASP9OPRM1 | |
| SCHEMBL6139839 | 0.86 | VEGFA (0.32) | CASP3CASP7 | |
| SCHEMBL27552241 | 0.82 | PLAU (0.39) | OPRM1OPRK1 | |
| SCHEMBL27552112 | 0.79 | CASP3 (0.37) | CASP3 | |
| SCHEMBL27580734 | 0.79 | CXCR2 (0.32) | — | |
| SCHEMBL7034500 | 0.78 | CXCR2 (0.45) | CASP3CASP7 | |
| SCHEMBL6137681 | 0.78 | CXCR2 (0.45) | CASP3CASP7 | |
| SCHEMBL6138062 | 0.78 | CXCR2 (0.45) | CASP3CASP7 | |
| SCHEMBL6563959 | 0.76 | CASP3 (0.45) | CASP3CASP7CASP1CASP9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1261329-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2005-08-17 | — | — | EP | disclosed |
| EP-1261329-A2 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-12-04 | — | — | EP | disclosed |
| WO-2001068033-A2 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2001-09-20 | — | — | WO | disclosed |