SCHEMBL6141595

SCHEMBL6141595

Cc1cc(NCc2cc(N)ccc2O)ccc1N

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 3/20 0.52
EGFR P00533 11/20 0.47
ALDH1A1 P00352 2/20 0.46
TDP1 Q9NUW8 2/20 0.46
CYP3A4 P08684 1/20 0.46
THRB P10828 1/20 0.46
ALOX15 P16050 1/20 0.46
RECQL P46063 1/20 0.46
HIF1A Q16665 1/20 0.46
PRKCI P41743 1/20 0.44
CA12 O43570 1/20 0.44
CA1 P00915 1/20 0.44
CA2 P00918 1/20 0.44
CA9 Q16790 1/20 0.44
PDE10A Q9Y233 1/20 0.43
ACHE P22303 1/20 0.43
APP P05067 1/20 0.43
RGS12 O14924 1/20 0.43
LCK P06239 1/20 0.43
CAMKK2 Q96RR4 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL2993240 0.99 MAPT (0.51) MAPTEGFRALDH1A1TDP1CYP3A4
SCHEMBL7158986 0.90 MAPT (0.66) MAPTEGFRALDH1A1TDP1PRKCI
SCHEMBL6267263 0.88 ALDH1A1 (0.44) MAPTALDH1A1TDP1CYP3A4THRB
Hydrochloric Acid SCHEMBL2993181 0.87 EGFR (0.62) MAPTEGFRALDH1A1TDP1CYP3A4
Hydrochloric Acid SCHEMBL6270613 0.86 ALDH1A1 (0.42) MAPTALDH1A1TDP1CYP3A4THRB
SCHEMBL27593775 0.85 MAPT (0.48) MAPTEGFRPRKCICA12CA1
Benzene SCHEMBL6842631 0.84 MAPT (0.43) MAPTALDH1A1TDP1CYP3A4THRB
SCHEMBL7163158 0.83 MAPT (0.61) MAPTEGFRALDH1A1THRBALOX15
SCHEMBL7158153 0.83 ARG1 (0.56) MAPTEGFRALDH1A1TDP1ALOX15
SCHEMBL2991426 0.82 EGFR (0.62) MAPTEGFRALDH1A1TDP1PRKCI

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1493731-A1 N-benzyl-p-phenylenediamine-derivatives containing colouring agents for keratin fibres and these derivatives Wella Aktiengesellschaft (DE) 2005-01-05 EP disclosed