Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP12 | P39900 | 9/20 | 0.55 |
| ▸ | MMP13 | P45452 | 5/20 | 0.55 |
| ▸ | MMP8 | P22894 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TACR3 | P29371 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6367993 | 0.88 | MMP12 (0.73) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL6451868 | 0.74 | RAB9A (0.54) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL12071144 | 0.72 | FOLH1 (0.52) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL12071229 | 0.72 | FOLH1 (0.52) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL6141835 | 0.71 | MMP12 (1.00) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL6368500 | 0.71 | MMP12 (1.00) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL6533949 | 0.71 | MMP12 (0.76) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL6533946 | 0.71 | MMP12 (0.76) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL8301905 | 0.70 | MMP12 (0.78) | MMP12MMP13MMP8MMP3MMP9 | |
| SCHEMBL6369477 | 0.70 | MMP12 (0.74) | MMP12MMP13MMP8MMP3MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1493739-A1 | Thiophene derivatives of aminoacids, process for the preparation thereof and compositions containing them | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | claimed |
| EP-1493739-A1 | Thiophene derivatives of aminoacids, process for the preparation thereof and compositions containing them | Warner-Lambert Company LLC (US) | 2005-01-05 | — | — | EP | disclosed |