Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 4/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 5/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | INSR | P06213 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29239834 | 0.77 | CA2 (0.57) | CA2APPCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL6592112 | 0.77 | CA12 (0.43) | CA2GAACYP1A2MAPTMEN1 | |
| SCHEMBL144455 | 0.76 | CA2 (0.56) | CA2APPCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL8694638 | 0.76 | CA2 (0.56) | CA2APPCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL6172684 | 0.76 | ALOX5 (0.54) | CA2CYP1A2CYP2C19CYP3A4RAB9A | |
| SCHEMBL3060793 | 0.74 | APP (0.60) | CA2APPGLAGAARAB9A | |
| SCHEMBL12675254 | 0.74 | CA2 (0.54) | CA2APPCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL1107212 | 0.74 | BACE1 (0.73) | CA2APPCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL5542989 | 0.74 | CA2 (0.54) | CA2APPCYP1A2CYP2C19CYP3A4 | |
| SCHEMBL8602480 | 0.74 | CA2 (0.54) | CA2APPGAACYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112851634-B | Preparation method of raloxifene hydrochloride | 江苏美迪克化学品有限公司 | 2021-11-16 | — | — | CN | disclosed |
| CN-112851634-A | Preparation method of raloxifene hydrochloride | 江苏美迪克化学品有限公司 | 2021-05-28 | — | — | CN | disclosed |
| CN-111138409-B | Preparation method of raloxifene hydrochloride and intermediate thereof | 江苏美迪克化学品有限公司 | 2021-02-02 | — | — | CN | disclosed |
| CN-111138409-A | Preparation method of raloxifene hydrochloride and intermediate thereof | 江苏美迪克化学品有限公司 | 2020-05-12 | — | — | CN | disclosed |
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |
| EP-3233828-B1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | HOFFMANN LA ROCHE (CH) | 2020-03-04 | — | — | EP | disclosed |
| US-9845291-B2 | Estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-12-19 | — | — | US | disclosed |
| US-9845291-B2 | Estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-12-19 | — | — | US | disclosed |
| US-9845291-B2 | Estrogen receptor modulators and uses thereof | GENENTECH, INC. (US) | 2017-12-19 | — | — | US | disclosed |
| EP-3233828-A1 | ESTROGEN RECEPTOR MODULATORS AND USES THEREOF | F. Hoffmann-La Roche AG (CH) | 2017-10-25 | — | — | EP | disclosed |
| US-5962698-A | PLASMINOGEN ACTIVATOR INHIBITOR | ELI LILLY AND COMPANY (US) | 1999-10-05 | — | — | US | disclosed |
| US-5948795-A | PLASMINOGEN ACTIVATOR INHIBITOR | ELI LILLY AND COMPANY (US) | 1999-09-07 | — | — | US | disclosed |
| EP-0863755-A4 | ANTITHROMBOTIC DIAMINES | LILLY CO ELI (US) | 1999-01-20 | — | — | EP | disclosed |
| EP-0863755-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1998-09-16 | — | — | EP | disclosed |
| EP-0826683-A1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-04 | — | — | EP | disclosed |
| EP-0819687-A1 | Benzothiophene compounds, and uses and formulations thereof | ELI LILLY AND COMPANY (US) | 1998-01-21 | — | — | EP | disclosed |
| WO-1997025033-A1 | ANTITHROMBOTIC DIAMINES | ELI LILLY AND COMPANY (US) | 1997-07-17 | — | — | WO | disclosed |
| WO-1997017069-A1 | METHODS FOR TREATING RESISTANT TUMORS | ELI LILLY AND COMPANY (US) | 1997-05-15 | — | — | WO | disclosed |
| EP-0773217-A1 | Benzothiphene derivatives for treating resistant tumors | ELI LILLY AND COMPANY (US) | 1997-05-14 | — | — | EP | disclosed |
| EP-0761669-A2 | Pentacyclic compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1997-03-12 | — | — | EP | disclosed |