Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | MTOR | P42345 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | GHSR | Q92847 | 1/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17668317 | 0.70 | HSD11B1 (0.46) | HSD11B1OPRK1HTTALDH1A1GAA | |
| SCHEMBL17668319 | 0.70 | HSD11B1 (0.46) | HSD11B1OPRK1HTTALDH1A1GAA | |
| SCHEMBL17668327 | 0.70 | HSD11B1 (0.46) | HSD11B1OPRK1HTTALDH1A1GAA | |
| SCHEMBL17668330 | 0.70 | HSD11B1 (0.46) | HSD11B1OPRK1HTTALDH1A1GAA | |
| SCHEMBL17668316 | 0.70 | HSD11B1 (0.46) | HSD11B1OPRK1HTTALDH1A1GAA | |
| SCHEMBL3275288 | 0.69 | NPC1 (0.46) | HSD11B1ALDH1A1GAA | |
| SCHEMBL17082729 | 0.68 | HSD11B1 (0.55) | HSD11B1OPRK1ALDH1A1 | |
| SCHEMBL13300220 | 0.67 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL27622558 | 0.67 | OPRM1 (0.49) | PTGDR2CHRM1DRD2ADRA2CSLC6A2 | |
| SCHEMBL27974245 | 0.66 | CNR2 (0.39) | SLC6A2SLC6A4OPRK1ALDH1A1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1581476-A2 | ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-10-05 | — | — | EP | disclosed |
| WO-2004056745-A2 | ADAMANTYL ACETAMIDES AS 11-BETA HYDROXYSTEROID DEHYDROGENASE INHIBITORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2004-07-08 | — | — | WO | disclosed |