Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | HPSE | Q9Y251 | 1/20 | 0.44 |
| ▸ | MGAM | O43451 | 9/20 | 0.43 |
| ▸ | GAA | P10253 | 9/20 | 0.43 |
| ▸ | SI | P14410 | 9/20 | 0.43 |
| ▸ | MGAM2 | Q2M2H8 | 9/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2340373 | 0.86 | PARP1 (0.55) | PARP1KDM4EHPGD | |
| SCHEMBL7350605 | 0.84 | PARP1 (0.46) | HRH4PARP1GABRPGABRDGABRA1 | |
| SCHEMBL7701684 | 0.84 | HRH4 (0.56) | HRH4ALDH1A1TDP1HPSEMGAM | |
| SCHEMBL9241387 | 0.80 | HRH4 (0.55) | HRH4PARP1ALDH1A1TDP1HPSE | |
| SCHEMBL12271578 | 0.79 | PARP1 (0.75) | HRH4PARP1PDE10A | |
| SCHEMBL1144691 | 0.79 | HRH4 (0.59) | HRH4ALDH1A1TDP1HPSEMGAM | |
| SCHEMBL27552206 | 0.78 | XDH (0.52) | HRH4ALDH1A1KDM4ENPC1HPGD | |
| SCHEMBL11745318 | 0.77 | HRH4 (0.58) | HRH4ALDH1A1TDP1HPSEMGAM | |
| SCHEMBL3137529 | 0.77 | HRH4 (0.58) | HRH4PARP1ALDH1A1TDP1HPSE | |
| SCHEMBL6142202 | 0.77 | KDM4E (0.36) | PARP1ALDH1A1TDP1GAAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0944604-B1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2005-01-12 | — | — | EP | disclosed |
| EP-0944601-B1 | GUANIDINYLAMINO HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | PROCTER & GAMBLE (US) | 2003-02-12 | — | — | EP | disclosed |
| EP-0944604-A1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998023596-A1 | GUANIDINYL HETEROCYCLE COMPOUNDS USEFUL AS ALPHA-2 ADRENOCEPTOR AGONISTS | THE PROCTER & GAMBLE COMPANY (US) | 1998-06-04 | — | — | WO | disclosed |