Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | NMT1 | P30419 | 2/20 | 0.37 |
| ▸ | DHODH | Q02127 | 1/20 | 0.37 |
| ▸ | NMT2 | O60551 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6148339 | 0.99 | KCNH2 (0.42) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL445305 | 0.90 | MAPT (0.40) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6145521 | 0.90 | KCNH2 (0.51) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6143500 | 0.89 | MAPT (0.39) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| Hydrochloric Acid SCHEMBL6144948 | 0.89 | MAPT (0.39) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL5706815 | 0.87 | KCNH2 (0.40) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL6144885 | 0.87 | KCNH2 (0.52) | KCNH2MAPTSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL7101341 | 0.85 | MAPT (0.43) | KCNH2MAPTSMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL6145924 | 0.85 | MEN1 (0.46) | KCNH2MAPTALDH1A1MEN1KMT2A | |
| SCHEMBL6147587 | 0.85 | SLC2A1 (0.48) | KCNH2SMN1; SMN2ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6903217-B2 | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them | AVENTIS PHARMA S.A. (FR) | 2005-06-07 | — | — | US | disclosed |
| US-20040147518-A1 | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them | AVENTIS PHARMA S.A. | 2004-07-29 | — | — | US | disclosed |
| US-6603005-B2 | Bactericides | AVENTIS PHARMA S.A. (FR) | 2003-08-05 | — | — | US | disclosed |
| US-20020111492-A1 | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them | NOVEXEL (FR) | 2002-08-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040147518-A1 | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them | SYNJ1, NCAPD2, SYNJ2 | KCNH2 81/4885MAPT 1162/4885SMN1; SMN2 292/4885 |
| US-20020111492-A1 | Heterocyclylalkylpiperidine derivatives, their preparation and compositions containing them | SYNJ1, NCAPD2, SYNJ2 | KCNH2 81/4885MAPT 1162/4885SMN1; SMN2 292/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.