SYNJ2

Synaptojanin-2 · O15056 · SYNJ2 on Sugi Atlas →

10,684 patent compounds predicted against SYNJ2, 7,177 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL347773	0.59	4/20
Maltitol (SCHEMBL1500680)	0.35	4/20
Ampelopsin (SCHEMBL134531)	1.00	3/20
Ampelopsin (SCHEMBL134532)	1.00	3/20
Ampelopsin (SCHEMBL723736)	1.00	3/20
Ampelopsin (SCHEMBL544092)	0.97	3/20
Albiflorin (SCHEMBL623462)	0.87	3/20
SCHEMBL49460	0.76	3/20
Taxifolin (SCHEMBL39570)	0.75	3/20
(+)-Taxifolin (SCHEMBL39786)	0.75	3/20
(+)-Taxifolin (SCHEMBL296323)	0.75	3/20
(+)-Taxifolin (SCHEMBL1707803)	0.75	3/20
SCHEMBL698777	0.72	3/20
Dihydrorobinetin (SCHEMBL432879)	0.64	3/20
Dihydrobinetin (SCHEMBL432880)	0.64	3/20
SCHEMBL94263	0.57	3/20
Fustin (SCHEMBL555237)	0.56	3/20
SCHEMBL1772595	0.55	3/20
Paeoniflorin (SCHEMBL549033)	0.49	3/20
Paeoniflorin (SCHEMBL410945)	0.49	3/20

Clinical trials — most relevant to SYNJ2 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
Evaluate Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	COMPLETED
The Synapse Project	PHASE2	COMPLETED
Mesenchymal Stem Cells Transplantation to Patients With Parkinson's Disease	PHASE1/PHASE2	UNKNOWN
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.	PHASE1	COMPLETED
Breakpoint Analysis of de Novo Apparently Balanced Chromosomal Translocations	EARLY_PHASE1	COMPLETED
Application of 18F-CP6A PET Imaging in Synucleinopathies	EARLY_PHASE1	NOT_YET_RECRUITING
Molecular Characterization of Induced Neuronal Cells in Parkinson's Disease	nan	UNKNOWN
Toward Molecular Profiling of Parkinson's Disease in Easily Accessible Biological Matrices	nan	ACTIVE_NOT_RECRUITING
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
The Epidemiology of Parkinson's Disease in Croatia and the Influence of Genetic Factors and Microbiota on the Progression and Treatment Outcomes of the Disease (GiOPARK)	nan	UNKNOWN
Gene Analysis of Parkinson's Disease	nan	COMPLETED
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients	nan	NOT_YET_RECRUITING
Study of the Genetic Factors Involved in Autism and Related Disorders	nan	RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Late Onset Alzheimer's Disease	nan	RECRUITING
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
Risk Factors for Progressive Supranuclear Palsy (PSP)	nan	COMPLETED
Role of Neurotransmission and Functional CNS Networks in Spasmodic Dysphonia	nan	COMPLETED
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.	nan	ENROLLING_BY_INVITATION
Drug Interaction With Genes in Parkinson's Disease	nan	UNKNOWN
Cell Studies of Parkinson's Disease	nan	COMPLETED
Genetic Variants Associated With Adolescent Suicide Attempts	nan	COMPLETED
Sensorimotor Gating in Schizophrenia	nan	COMPLETED
Rostock International Parkinson's Disease Study (ROPAD)	nan	COMPLETED
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a SYNJ2 binder may also engage these)

Protein	Name	Similarity
O55207	—	1.000	O55207 →
Q9D2G5	—	1.000	Q9D2G5 →
Q8CHC4	—	0.998	Q8CHC4 →
Q62910	—	0.996	Q62910 →
O18964	—	0.996	O18964 →
SYNJ1	Synaptojanin-1	0.994	landscape →
Q7X911	—	0.992	Q7X911 →
Q5XI69	—	0.991	Q5XI69 →
O43001	—	0.991	O43001 →
F4IDQ6	—	0.991	F4IDQ6 →
Q6PE54	—	0.990	Q6PE54 →
Q96328	—	0.990	Q96328 →
P50942	—	0.990	P50942 →
Q6GM29	—	0.989	Q6GM29 →
G5ECL2	—	0.988	G5ECL2 →
A6QL88	—	0.988	A6QL88 →
Q03603	—	0.988	Q03603 →
P0CE10	—	0.987	P0CE10 →
Q5R864	—	0.987	Q5R864 →
SACM1L	Phosphatidylinositol-3-phosphatase SAC1	0.987	landscape →
Q9EP69	—	0.987	Q9EP69 →
B4NBB0	—	0.987	B4NBB0 →
Q9TXI7	—	0.987	Q9TXI7 →
P34647	—	0.987	P34647 →
Q12271	—	0.987	Q12271 →
P06623	—	0.987	P06623 →
Q9H1H9	—	0.987	Q9H1H9 →
Q3TIU4	—	0.987	Q3TIU4 →
P40559	—	0.987	P40559 →
Q9STV0	—	0.987	Q9STV0 →