SYNJ1

Synaptojanin-1 · O43426 · SYNJ1 on Sugi Atlas →

156 patent compounds predicted against SYNJ1, 111 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
Pyrvinium (SCHEMBL149062)	1.00	1/20
Pyrvinium (SCHEMBL149063)	1.00	1/20
Pyrvinium (SCHEMBL16291465)	1.00	1/20
Pyrvinium (SCHEMBL29387513)	1.00	1/20
Pyrvinium (SCHEMBL30383133)	1.00	1/20
Pyrvinium (SCHEMBL30642307)	1.00	1/20
Pyrvinium (SCHEMBL646419)	0.98	1/20
Pyrvinium (SCHEMBL646420)	0.98	1/20
Pyrvinium (SCHEMBL21111996)	0.98	1/20
Pyrvinium (SCHEMBL4877919)	0.89	1/20
Pyrvinium (SCHEMBL4881741)	0.89	1/20
Pyrvinium (SCHEMBL4881744)	0.89	1/20
Pyrvinium (SCHEMBL19457668)	0.89	1/20
Pyrvinium (SCHEMBL23275434)	0.87	1/20
Pyrvinium (SCHEMBL19457669)	0.82	1/20
Pyrvinium (SCHEMBL19457812)	0.82	1/20
SCHEMBL647337	0.81	1/20
SCHEMBL14007212	0.78	1/20
SCHEMBL10024115	0.76	1/20
SCHEMBL5318897	0.76	1/20

Clinical trials — most relevant to SYNJ1 by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Endoxifen in Bipolar I Disorder Patients	PHASE3	ACTIVE_NOT_RECRUITING
The Synapse Project	PHASE2	COMPLETED
Mesenchymal Stem Cells Transplantation to Patients With Parkinson's Disease	PHASE1/PHASE2	UNKNOWN
Effects of Lithium Therapy on Blood-based Therapeutic Targets in Parkinson's Disease.	PHASE1	COMPLETED
Nilotinib in Huntington's Disease	PHASE1	UNKNOWN
Application of 18F-CP6A PET Imaging in Synucleinopathies	EARLY_PHASE1	NOT_YET_RECRUITING
The Epidemiology of Parkinson's Disease in Croatia and the Influence of Genetic Factors and Microbiota on the Progression and Treatment Outcomes of the Disease (GiOPARK)	nan	UNKNOWN
Toward Molecular Profiling of Parkinson's Disease in Easily Accessible Biological Matrices	nan	ACTIVE_NOT_RECRUITING
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease	nan	UNKNOWN
Investigating Phenotypic, Epigenetic, and NeuroGenetic Traits in Rare and Ultra-rare Neurodevelopmental Disorders (Project PENGUIN)	nan	RECRUITING
Biomarker Research in Inherited Movement Disorders	nan	RECRUITING
Gene Analysis of Parkinson's Disease	nan	COMPLETED
Molecular Characterization of Induced Neuronal Cells in Parkinson's Disease	nan	UNKNOWN
Implementation of Molecular Diagnostic Pathways	nan	UNKNOWN
Susceptibility Genes in Autism Spectrum Disorders	nan	COMPLETED
Understanding Alpha-Synuclein Spread in Parkinson's Disease Through Blood Biomarkers and Neuroimaging	nan	NOT_YET_RECRUITING
Consortium On Risk for Early-onset Parkinson's Disease (CORE PD)	nan	COMPLETED
Study of the Genetic Factors Involved in Autism and Related Disorders	nan	RECRUITING
Genetic Characterization of Parkinson's Disease	nan	COMPLETED
Genes, Proteins, and Metabolites in Drug-resistant Epilepsy (DRE) Patients	nan	NOT_YET_RECRUITING
STXBP1 and SYNGAP1 Related Disorders Natural History Study	nan	RECRUITING
Rostock International Parkinson's Disease Study (ROPAD)	nan	COMPLETED
The Genetic Characterization of Dementia	nan	COMPLETED
Late Onset Alzheimer's Disease	nan	RECRUITING
Genetic Analysis of Parkinson's Disease	nan	COMPLETED
Investigating Genetic Status in Patients Presenting to Clinic	nan	RECRUITING
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services	nan	UNKNOWN
Understanding Mechanisms of Synaptic Degeneration Underlying Clinical Symptoms in Patients With MDs and NDs.	nan	ENROLLING_BY_INVITATION
A Study Into the Underlying Biochemical Pathways Involved in Parkinson's Disease, Such as Mitochondrial (Cellular Powerhouse) Dysfunction	nan	COMPLETED
NMR Based Metabolomic Study of Serum Biomarkers in Patients With Parkinson's Disease and Atypical Parkinsonian Syndrome	nan	UNKNOWN

Related proteins — ESM-2 sequence neighbours (a SYNJ1 binder may also engage these)

Protein	Name	Similarity
Q8CHC4	—	1.000	Q8CHC4 →
O18964	—	1.000	O18964 →
Q62910	—	1.000	Q62910 →
O55207	—	0.999	O55207 →
Q9D2G5	—	0.999	Q9D2G5 →
SYNJ2	Synaptojanin-2	0.999	landscape →
O43001	—	0.999	O43001 →
G5ECL2	—	0.998	G5ECL2 →
P50942	—	0.997	P50942 →
Q12271	—	0.996	Q12271 →
Q7X911	—	0.994	Q7X911 →
Q96328	—	0.994	Q96328 →
F4IDQ6	—	0.992	F4IDQ6 →
Q6GM29	—	0.992	Q6GM29 →
P40559	—	0.991	P40559 →
Q5XI69	—	0.991	Q5XI69 →
A6QL88	—	0.991	A6QL88 →
Q84WU9	—	0.991	Q84WU9 →
Q03603	—	0.991	Q03603 →
B0XDC4	—	0.990	B0XDC4 →
Q6PE54	—	0.990	Q6PE54 →
P34647	—	0.990	P34647 →
Q9H1H9	—	0.990	Q9H1H9 →
B4NBB0	—	0.990	B4NBB0 →
O14134	—	0.990	O14134 →
Q9M2Q4	—	0.990	Q9M2Q4 →
SACM1L	Phosphatidylinositol-3-phosphatase SAC1	0.990	landscape →
Q6C2R8	—	0.990	Q6C2R8 →
Q1DKI1	—	0.990	Q1DKI1 →
Q9W4N2	—	0.990	Q9W4N2 →