Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.58 |
| ▸ | GAA | P10253 | 2/20 | 0.58 |
| ▸ | ESR1 | P03372 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | DHODH | Q02127 | 2/20 | 0.50 |
| ▸ | VDR | P11473 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6934698 | 0.88 | LMNA (0.53) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL3841651 | 0.87 | LMNA (0.55) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL8499352 | 0.87 | DHODH (0.59) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL15249773 | 0.86 | DHODH (0.48) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL3142288 | 0.84 | LMNA (0.52) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL11260400 | 0.84 | LMNA (0.52) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL11110671 | 0.84 | LMNA (0.52) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL11110675 | 0.82 | LMNA (0.51) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL28027224 | 0.82 | LMNA (0.50) | MEN1KMT2AGAAESR1ESR2 | |
| SCHEMBL8558118 | 0.81 | DHODH (0.51) | MEN1KMT2AGAAESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1556342-A1 | PHENETHANOLAMINE DERIVATIVE FOR THE TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2005-07-27 | — | — | EP | disclosed |
| WO-2004037773-A1 | PHENETHANOLAMINE DERIVATIVE FOR THE TREATMENT OF RESPIRATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2004-05-06 | — | — | WO | disclosed |