Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FURIN | P09958 | 6/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | F10 | P00742 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.47 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.47 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.47 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8446705 | 1.00 | FURIN (0.56) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL8445590 | 1.00 | FURIN (0.56) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL5442050 | 1.00 | FURIN (0.56) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL5973917 | 1.00 | FURIN (0.56) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL5973945 | 0.98 | FURIN (0.56) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL6150719 | 0.95 | FURIN (0.56) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL5973841 | 0.93 | FURIN (0.55) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL5974478 | 0.93 | FURIN (0.55) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL4914693 | 0.93 | FURIN (0.55) | FURINMEN1KMT2AF10PARP1 | |
| SCHEMBL5974904 | 0.93 | FURIN (0.55) | FURINMEN1KMT2AF10PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004016258-A1 | THERAPEUTICAL USE OF GUANYLHYDRAZONES FOR TREATING DISEASES ASSOCIATED WITH DENDRITIC CELL MATURATION | MONDOBIOTECH LABORATORIES ANSTALT (CH) | 2004-02-26 | — | — | WO | claimed |
| US-20030203969-A1 | Pharmaceutically active aromatic guanylhydrazones | AXXIMA PHARMACEUTICALS AG (DE) | 2003-10-30 | — | — | US | claimed |
| WO-2003006426-A1 | AROMATIC GUANYLHYDRAZONES AS EFFECTIVE COMPOUNDS AGAINST NEURODISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2003-01-23 | — | — | WO | claimed |
| EP-1255541-A2 | PHARMACEUTICALLY ACTIVE AROMATIC GUANYLHYDRAZONES | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2002-11-13 | — | — | EP | claimed |
| WO-2002000613-A2 | INHIBITORS OF HEPATITIS B VIRUS INFECTION | AXXIMA PHARMACEUTICALS AG (DE) | 2002-01-03 | — | — | WO | claimed |
| WO-2001056553-A2 | PHARMACEUTICALLY ACTIVE AROMATIC GUANYLHYDRAZONES | AXXIMA PHARMACEUTICALS AG (DE) | 2001-08-09 | — | — | WO | claimed |
| EP-1255541-B1 | AROMATIC GUANYLHYDRAZONE FOR THE TREATMENT OF RESISTANT VIRAL INFECTIONS | BEVEC DORIAN (DE) | 2005-11-09 | — | — | EP | disclosed |
| WO-2004016258-A1 | THERAPEUTICAL USE OF GUANYLHYDRAZONES FOR TREATING DISEASES ASSOCIATED WITH DENDRITIC CELL MATURATION | MONDOBIOTECH LABORATORIES ANSTALT (CH) | 2004-02-26 | — | — | WO | disclosed |
| EP-1389480-A1 | Therapeutical use of guanylhydrazones for the inhibition of CD83 dependent processes and dendritic cell maturation | Mondobiotech Interferon SA (CH) | 2004-02-18 | — | — | EP | disclosed |
| US-20030203969-A1 | Pharmaceutically active aromatic guanylhydrazones | AXXIMA PHARMACEUTICALS AG (DE) | 2003-10-30 | — | — | US | disclosed |
| WO-2003006426-A1 | AROMATIC GUANYLHYDRAZONES AS EFFECTIVE COMPOUNDS AGAINST NEURODISEASES | AXXIMA PHARMACEUTICALS AG (DE) | 2003-01-23 | — | — | WO | disclosed |
| EP-1255541-A2 | PHARMACEUTICALLY ACTIVE AROMATIC GUANYLHYDRAZONES | Axxima Pharmaceuticals Aktiengesellschaft (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2002000613-A2 | INHIBITORS OF HEPATITIS B VIRUS INFECTION | AXXIMA PHARMACEUTICALS AG (DE) | 2002-01-03 | — | — | WO | disclosed |
| WO-2001056553-A2 | PHARMACEUTICALLY ACTIVE AROMATIC GUANYLHYDRAZONES | AXXIMA PHARMACEUTICALS AG (DE) | 2001-08-09 | — | — | WO | disclosed |
| EP-0746312-A4 | GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS | PICOWER INST MED RES (US) | 1999-05-26 | — | — | EP | disclosed |
| EP-0746312-A1 | GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 1996-12-11 | — | — | EP | disclosed |
| WO-1995019767-A1 | GUANYLHYDRAZONES FOR TREATING INFLAMMATORY CONDITIONS | THE PICOWER INSTITUTE FOR MEDICAL RESEARCH (US) | 1995-07-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030203969-A1 | Pharmaceutically active aromatic guanylhydrazones | DHPS, GGPS1, GMPS | FURIN 2883/4885MEN1 4245/4885KMT2A 4547/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.