Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4061712 | 0.77 | TSHR (0.68) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL7916957 | 0.76 | SMN1; SMN2 (0.58) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL5712121 | 0.74 | MEN1 (0.57) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL579380 | 0.74 | SMN1; SMN2 (0.55) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL579067 | 0.73 | ALDH1A1 (0.55) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6701189 | 0.71 | MEN1 (0.62) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL6153032 | 0.71 | MAPT (0.58) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL9880035 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL578877 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 | |
| SCHEMBL578878 | 0.70 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |