Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12077838 | 0.76 | MAPT (0.73) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL17645850 | 0.74 | MAPT (1.00) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL4062112 | 0.73 | MAPT (0.78) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL671244 | 0.72 | SMN1; SMN2 (0.69) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6150866 | 0.71 | SMN1; SMN2 (0.48) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL14275127 | 0.70 | SMN1; SMN2 (0.74) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL16894151 | 0.69 | SMN1; SMN2 (0.60) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL2569770 | 0.69 | MAPT (0.61) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL14744375 | 0.67 | MAPT (0.64) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A | |
| SCHEMBL6701096 | 0.67 | SMN1; SMN2 (0.61) | MAPTSMN1; SMN2ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1492785-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2005-01-05 | — | — | EP | disclosed |
| WO-2003082853-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2003-10-09 | — | — | WO | disclosed |