Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 12/20 | 0.56 |
| ▸ | PPARA | Q07869 | 10/20 | 0.56 |
| ▸ | PPARD | Q03181 | 6/20 | 0.56 |
| ▸ | LTB4R | Q15722 | 4/20 | 0.56 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6661730 | 0.93 | PPARG (0.57) | PPARGPPARAPPARDLTB4RLTB4R2 | |
| SCHEMBL3963060 | 0.87 | PPARG (0.54) | PPARGPPARAPPARDMAPK1SMN1; SMN2 | |
| SCHEMBL3963064 | 0.87 | PPARG (0.54) | PPARGPPARAPPARDMAPK1SMN1; SMN2 | |
| SCHEMBL6150234 | 0.86 | PPARG (0.53) | PPARGPPARAPPARDALOX5 | |
| SCHEMBL6150258 | 0.85 | PPARA (0.54) | PPARGPPARAPPARDMAPK1NPC1 | |
| SCHEMBL5721437 | 0.84 | PPARG (0.54) | PPARGPPARAPPARDALOX5 | |
| SCHEMBL6150621 | 0.84 | PPARG (0.54) | PPARGPPARAPPARDALOX5 | |
| SCHEMBL6151404 | 0.83 | PPARA (0.52) | PPARGPPARAPPARDMAPK1NPC1 | |
| SCHEMBL5358205 | 0.80 | PPARA (0.56) | PPARGPPARAPPARDMAPK1ALOX5 | |
| SCHEMBL3966640 | 0.80 | PPARA (0.56) | PPARGPPARAPPARDMAPK1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1517882-A1 | AMIDE LINKER PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2005-03-30 | — | — | EP | disclosed |
| WO-2004000789-A1 | AMIDE LINKER PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR MODULATORS | ELI LILLY AND COMPANY (US) | 2003-12-31 | — | — | WO | disclosed |