Known targets — ChEMBL curated mechanism
PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Lysine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSR | P00390 | 1/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 6/20 | 0.38 |
| ▸ | DPP4 | P27487 | 4/20 | 0.38 |
| ▸ | DPP8 | Q6V1X1 | 4/20 | 0.38 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.38 |
| ▸ | FAP | Q12884 | 1/20 | 0.38 |
| ▸ | ARG2 | P78540 | 4/20 | 0.33 |
| ▸ | ARG1 | P05089 | 3/20 | 0.33 |
| ▸ | TLR2 | O60603 | 2/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.32 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2043828 | 0.88 | NOS2 (0.37) | DPP7DPP4DPP8DPP9FAP | |
| Lysine SCHEMBL15942522 | 0.88 | GSR (0.47) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL1537262 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL4296375 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL28079281 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL23834597 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL11660661 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL1696608 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Lysine SCHEMBL5227175 | 0.84 | GSR (0.57) | GSRDPP7DPP4DPP8DPP9 | |
| Proline SCHEMBL140698 | 0.84 | TLR2 (0.34) | DPP7DPP4DPP8DPP9FAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1513502-B1 | COMBINATION THERAPY FOR RESPIRATORY DISORDERS | OCKHAM BIOTECH LTD (GB) | 2015-12-30 | — | — | EP | disclosed |
| EP-1513502-A1 | COMBINATION THERAPY FOR RESPIRATORY DISORDERS | University of Southampton (GB) | 2005-03-16 | — | — | EP | disclosed |
| WO-2003068188-A1 | COMBINATION THERAPY FOR RESPIRATORY DISORDERS | UNIVERSITY OF SOUTHAMPTON (GB) | 2003-08-21 | — | — | WO | disclosed |