Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Proline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR2 | O60603 | 2/20 | 0.34 |
| ▸ | NOS2 | P35228 | 2/20 | 0.34 |
| ▸ | NOS3 | P29474 | 1/20 | 0.34 |
| ▸ | NOS1 | P29475 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.32 |
| ▸ | FAP | Q12884 | 1/20 | 0.32 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.32 |
| ▸ | PRCP | P42785 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2043828 | 0.96 | NOS2 (0.37) | TLR2NOS2NOS3NOS1DPP4 | |
| Proline SCHEMBL3519298 | 0.95 | TLR2 (0.32) | TLR2NOS2NOS3NOS1DPP4 | |
| Alanine SCHEMBL5970554 | 0.90 | TLR2 (0.36) | TLR2NOS2NOS3NOS1DPP4 | |
| Proline SCHEMBL4604674 | 0.87 | TLR2 (0.34) | TLR2NOS2NOS3NOS1DPP4 | |
| Proline SCHEMBL3105891 | 0.87 | KMT2A (0.38) | MEN1KMT2ABLM | |
| SCHEMBL3100834 | 0.85 | TLR2 (0.30) | TLR2 | |
| Proline SCHEMBL2588288 | 0.85 | TLR2 (0.30) | TLR2 | |
| Lysine SCHEMBL6151465 | 0.84 | GSR (0.49) | TLR2DPP4DPP8DPP9FAP | |
| Proline SCHEMBL8582773 | 0.83 | TLR2 (0.34) | TLR2NOS2NOS3NOS1DPP7 | |
| Phenylalanine SCHEMBL5672080 | 0.82 | SLC7A5 (0.51) | DPP4DPP8DPP9ELANESLC1A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8673854-B2 | Prophylactic agent for heart failure | CALPIS CO., LTD. (JP) | 2014-03-18 | — | — | US | disclosed |
| EP-2138184-B1 | TRIPEPTIDES FOR USE IN PREVENTING KIDNEY GLOMERULAR DISEASE | CALPIS CO LTD (JP) | 2013-09-18 | — | — | EP | disclosed |
| EP-2130546-B1 | TRIPEPTIDES FOR USE IN TREATING HEART WALL THICKENING | CALPIS CO LTD (JP) | 2013-02-27 | — | — | EP | disclosed |
| US-20120077735-A1 | PROPHYLACTIC AGENT FOR RENAL FAILURE | HIROTA TATSUHIKO (JP) | 2012-03-29 | — | — | US | disclosed |
| US-20120058947-A1 | PROPHYLACTIC AGENT FOR HEART FAILURE | ASAHI GROUP FOODS, LTD. (JP) | 2012-03-08 | — | — | US | disclosed |
| US-20100022748-A1 | PROPHYLACTIC AGENT FOR RENAL FAILURE | CALPIS CO., LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| US-20100022747-A1 | PROPHYLACTIC AGENT FOR HEART FAILURE | CALPIS CO., LTD. (JP) | 2010-01-28 | — | — | US | disclosed |
| EP-2138184-A1 | PROPHYLACTIC AGENT FOR RENAL FAILURE | Calpis Co., Ltd. (JP) | 2009-12-30 | — | — | EP | disclosed |
| EP-2130546-A1 | PROPHYLACTIC AGENT FOR HEART FAILURE | Calpis Co., Ltd. (JP) | 2009-12-09 | — | — | EP | disclosed |