Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 4/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.42 |
| ▸ | MC5R | P33032 | 1/20 | 0.42 |
| ▸ | MC3R | P41968 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 12/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 12/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | HTR7 | P34969 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5134499 | 0.88 | HTR1A (0.40) | HCRTR1HCRTR2HTR1AHTR7 | |
| SCHEMBL5135099 | 0.83 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3MC4RMC5R | |
| SCHEMBL5137378 | 0.77 | MC4R (0.45) | SLC6A2SLC6A4SLC6A3MC4RMC5R | |
| SCHEMBL5135649 | 0.74 | C5AR1 (0.39) | — | |
| SCHEMBL5136534 | 0.72 | AGER (0.42) | — | |
| SCHEMBL5137387 | 0.72 | MEN1 (0.57) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL5136513 | 0.72 | TACR1 (0.43) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL5137126 | 0.72 | AGER (0.41) | — | |
| SCHEMBL5135774 | 0.72 | HSD17B2 (0.40) | SLC6A2SLC6A4KCNH2 | |
| SCHEMBL5136654 | 0.70 | MEN1 (0.49) | SLC6A2SLC6A4KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1487796-A4 | SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS | NEUROGEN CORP (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1487796-A1 | SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2004-12-22 | — | — | EP | disclosed |
| WO-2003082826-A1 | SUBSTITUTED BIARYL AMIDES AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |