Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 17/20 | 0.47 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152455 | 0.91 | CYP19A1 (0.44) | ESR1 | |
| SCHEMBL5983904 | 0.90 | ESR1 (0.48) | ESR1ESR2 | |
| SCHEMBL4640167 | 0.89 | ESR1 (0.57) | ESR1ESR2 | |
| SCHEMBL6158194 | 0.88 | ESR1 (0.45) | ESR1ESR2ARHSD17B3 | |
| SCHEMBL5416855 | 0.86 | ESR1 (0.54) | ESR1ESR2 | |
| SCHEMBL4619222 | 0.85 | ESR1 (0.55) | ESR1ESR2 | |
| SCHEMBL6153596 | 0.81 | CYP19A1 (0.51) | ESR1ESR2 | |
| SCHEMBL4641971 | 0.81 | ESR1 (0.59) | ESR1ESR2 | |
| SCHEMBL6152326 | 0.80 | CYP19A1 (0.51) | ESR1 | |
| SCHEMBL4621568 | 0.79 | ESR1 (0.55) | ESR1ESR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497277-A1 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003089422-A1 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-10-30 | — | — | WO | disclosed |