Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD4 | P21917 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | ESR1 | P03372 | 6/20 | 0.40 |
| ▸ | LTA4H | P09960 | 2/20 | 0.39 |
| ▸ | MAOB | P27338 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | BCHE | P06276 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5983904 | 0.91 | ESR1 (0.48) | CYP19A1ESR1LTA4HESR2 | |
| SCHEMBL6152455 | 0.90 | CYP19A1 (0.44) | CYP19A1DRD2DRD4DRD3ESR1 | |
| SCHEMBL5426736 | 0.85 | ESR1 (0.57) | CYP19A1DRD2DRD4DRD3ESR1 | |
| SCHEMBL4639676 | 0.84 | CYP19A1 (0.58) | CYP19A1DRD2DRD4DRD3ESR1 | |
| SCHEMBL4640645 | 0.84 | HSP90AA1 (0.39) | CYP19A1ESR1LTA4H | |
| SCHEMBL6158194 | 0.81 | ESR1 (0.45) | ESR1ESR2 | |
| SCHEMBL6152270 | 0.81 | ESR1 (0.47) | ESR1ESR2 | |
| SCHEMBL6152326 | 0.81 | CYP19A1 (0.51) | CYP19A1DRD2DRD4DRD3ESR1 | |
| SCHEMBL4639596 | 0.81 | CYP19A1 (0.62) | CYP19A1ESR1ESR2 | |
| SCHEMBL5142313 | 0.79 | ESR1 (0.50) | CYP19A1DRD2DRD4DRD3ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1497277-A1 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | Signal Pharmaceuticals, Inc. (US) | 2005-01-19 | — | — | EP | disclosed |
| WO-2003089422-A1 | BENZOPYRANONE COMPOUNDS, COMPOSITIONS THEREOF, AND METHODS OF TREATMENT THEREWITH | SIGNAL PHARMACEUTICALS, INC. (US) | 2003-10-30 | — | — | WO | disclosed |