Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 8/20 | 0.47 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.44 |
| ▸ | MLNR | O43193 | 3/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 2/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | DHFR | P00374 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5863865 | 0.88 | PDK1 (0.44) | PDK1PDK2PDK3PDK4MLNR | |
| SCHEMBL5864049 | 0.78 | TP53 (0.40) | PDK1PDK2PDK3PDK4MLNR | |
| SCHEMBL5863857 | 0.75 | LTA4H (0.48) | KDM4ELTA4HHTTALDH1A1 | |
| SCHEMBL5863902 | 0.75 | KDM4E (0.40) | KDM4EPOLBESR1ESR2ALDH1A1 | |
| SCHEMBL5863962 | 0.73 | LTA4H (0.40) | PDK1KDM4ELTA4HESR1ESR2 | |
| SCHEMBL5863673 | 0.73 | LTA4H (0.59) | KDM4ELTA4HDHFRALDH1A1SMN1; SMN2 | |
| SCHEMBL5863827 | 0.72 | LTA4H (0.37) | KDM4ELTA4HDHFRALDH1A1SMN1; SMN2 | |
| SCHEMBL5863668 | 0.71 | KDR (0.60) | LTA4HHTTSMN1; SMN2 | |
| SCHEMBL5863769 | 0.70 | PDK1 (0.52) | PDK1PDK2PDK3PDK4KDM4E | |
| SCHEMBL5864000 | 0.69 | LTA4H (0.36) | KDM4EPOLBLTA4HDHFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1542967-A1 | AMIDE AND SULFONAMIDE LIGANDS FOR THE ESTROGEN RECEPTOR | Pfizer Products Inc. (US) | 2005-06-22 | — | — | EP | disclosed |
| WO-2004026823-A1 | AMIDE AND SULFONAMIDE LIGANDS FOR THE ESTROGEN RECEPTOR | PFIZER PRODUCTS INC. (US) | 2004-04-01 | — | — | WO | disclosed |