Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.31 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153116 | 0.92 | CCR3 (0.33) | CCR3MC4RMAPK1BCHEACHE | |
| SCHEMBL6152408 | 0.90 | CCR3 (0.36) | CCR3KDM4EALDH1A1MAPK1BDKRB1 | |
| SCHEMBL6152456 | 0.90 | BDKRB1 (0.35) | CCR3BDKRB1 | |
| SCHEMBL6943528 | 0.89 | CCR3 (0.36) | CCR3KDM4EALDH1A1MC4RMAPK1 | |
| SCHEMBL6153146 | 0.88 | CCR3 (0.34) | CCR3KDM4EALDH1A1MAPK1MEN1 | |
| SCHEMBL7838559 | 0.87 | SIGMAR1 (0.42) | CCR3KDM4EALDH1A1MC4RMEN1 | |
| SCHEMBL6152315 | 0.86 | BDKRB1 (0.35) | MC4RBDKRB1 | |
| SCHEMBL6152863 | 0.86 | MEN1 (0.36) | CCR3KDM4EALDH1A1MEN1KMT2A | |
| SCHEMBL6152832 | 0.86 | CCR3 (0.33) | CCR3KDM4EALDH1A1MAPK1BDKRB1 | |
| SCHEMBL6152716 | 0.85 | CCR3 (0.33) | CCR3KDM4EALDH1A1MAPK1BDKRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | claimed |
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |