Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.36 |
| ▸ | CYP2A13 | Q16696 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.33 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | ABHD6 | Q9BV23 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152262 | 0.92 | HCRTR1 (0.35) | MEN1KMT2AHRH3CYP2A13CCR3 | |
| SCHEMBL6152510 | 0.91 | POLB (0.33) | HRH3CCR3KDM4ETSHR | |
| SCHEMBL6152408 | 0.89 | CCR3 (0.36) | MEN1KMT2ACCR3KDM4EALDH1A1 | |
| SCHEMBL6152865 | 0.89 | MEN1 (0.36) | MEN1KMT2AMGLLKDM4EALDH1A1 | |
| SCHEMBL6943528 | 0.88 | CCR3 (0.36) | MEN1KMT2ACCR3KDM4EALDH1A1 | |
| SCHEMBL6153146 | 0.86 | CCR3 (0.34) | MEN1KMT2ACCR3KDM4EALDH1A1 | |
| SCHEMBL6152430 | 0.86 | CCR3 (0.34) | MEN1KMT2ACCR3KDM4EALDH1A1 | |
| SCHEMBL7838559 | 0.85 | SIGMAR1 (0.42) | MEN1KMT2ACCR3MGLLKDM4E | |
| SCHEMBL6152975 | 0.85 | CCR3 (0.33) | KMT2ACCR3KDM4EALDH1A1 | |
| SCHEMBL6152832 | 0.84 | CCR3 (0.33) | CCR3KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |