Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A3 | Q01959 | 14/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 13/20 | 0.62 |
| ▸ | SLC6A2 | P23975 | 8/20 | 0.62 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.60 |
| ▸ | CHRNG | P07510 | 4/20 | 0.60 |
| ▸ | ITGA5 | P08648 | 4/20 | 0.60 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.60 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.60 |
| ▸ | CHRNB4 | P30926 | 4/20 | 0.60 |
| ▸ | CHRNA3 | P32297 | 4/20 | 0.60 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.60 |
| ▸ | CHRND | Q07001 | 4/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152828 | 1.00 | SLC6A3 (0.62) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL6152899 | 0.90 | SLC6A3 (0.76) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6152901 | 0.90 | SLC6A3 (0.76) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL8291598 | 0.85 | SLC6A3 (0.83) | SLC6A3SLC6A4SLC6A2CHRNA1CHRNG | |
| SCHEMBL14173845 | 0.83 | SLC6A3 (0.82) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5731247 | 0.83 | SLC6A3 (0.82) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL5731249 | 0.83 | SLC6A3 (0.82) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6574444 | 0.79 | SLC6A3 (0.74) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL6574468 | 0.79 | SLC6A3 (0.74) | SLC6A3SLC6A4SLC6A2 | |
| SCHEMBL7343838 | 0.79 | SLC6A3 (0.74) | SLC6A3SLC6A4SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0897922-B1 | Cocaine receptor binding ligands | RES TRIANGLE INST (US) | 2005-07-20 | — | — | EP | disclosed |
| EP-0897922-A2 | Cocaine receptor binding ligands | RESEARCH TRIANGLE INSTITUTE (US) | 1999-02-24 | — | — | EP | disclosed |
| US-5736123-A | TRIALKYLTIN CHEMICAL INTERMEDIATES | RESEARCH TRIANGLE INSTITUTE (US) | 1998-04-07 | — | — | US | disclosed |
| US-5496953-A | DOPAMINE TRANSPORTER SITES, RADIOACTIVE, DIAGNOSIS, IMAGING, NORTROPANE DERIVATIVES | RESEARCH TRIANGLE INSTITUTE (US) | 1996-03-05 | — | — | US | disclosed |
| US-5380848-A | 8-azabicyclo(3.2.1)octanes | RESEARCH TRIANGLE INSTITUTE (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993009814-A1 | COCAINE RECEPTOR BINDING LIGANDS | RESEARCH TRIANGLE INSTITUTE (US) | 1993-05-27 | — | — | WO | disclosed |