Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 8/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 7/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3528183 | 0.88 | KDM4E (0.41) | LMNAKDM4EOPRD1OPRK1 | |
| SCHEMBL6264708 | 0.86 | OPRM1 (0.43) | OPRD1OPRM1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL3525986 | 0.85 | KMT2A (0.48) | OPRD1OPRM1OPRK1SLC22A1SLC6A4 | |
| SCHEMBL17078046 | 0.79 | OPRM1 (0.44) | LMNAOPRM1ALDH1A1SMN1; SMN2APP | |
| SCHEMBL3527223 | 0.78 | OPRM1 (0.38) | MAPTOPRD1OPRM1OPRK1SLC6A4 | |
| SCHEMBL3523983 | 0.78 | CRHBP (0.41) | LMNAKDM4EMAPTALDH1A1HPGD | |
| SCHEMBL3527253 | 0.78 | TSHR (0.44) | OPRD1OPRK1 | |
| SCHEMBL3529464 | 0.77 | APP (0.47) | MAPTOPRD1OPRM1OPRK1SLC22A1 | |
| SCHEMBL3523767 | 0.76 | JAK1 (0.45) | MAPTOPRD1OPRK1 | |
| SCHEMBL3526604 | 0.75 | GRM5 (0.36) | KDM4EMAPTOPRD1OPRM1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1569646-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2005-09-07 | — | — | EP | disclosed |
| WO-2004054974-A2 | PIPERIDINE DERIVATIVES AS CCR5 ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2004-07-01 | — | — | WO | disclosed |