Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGER3 | P43115 | 10/20 | 0.46 |
| ▸ | PTGER2 | P43116 | 9/20 | 0.46 |
| ▸ | PTGER4 | P35408 | 8/20 | 0.46 |
| ▸ | PTGDR | Q13258 | 4/20 | 0.44 |
| ▸ | TBXA2R | P21731 | 3/20 | 0.44 |
| ▸ | BCHE | P06276 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PTGER1 | P34995 | 3/20 | 0.43 |
| ▸ | SCN1A | P35498 | 1/20 | 0.43 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.43 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.43 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.43 |
| ▸ | PTGFR | P43088 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6153061 | 1.00 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2HPGDPTGER3 | |
| SCHEMBL8573281 | 0.76 | PTGER3 (0.57) | KDM4EPTGER3PTGER2PTGER4PTGDR | |
| SCHEMBL1150939 | 0.75 | PTGER3 (0.63) | SMN1; SMN2PTGER3PTGER2PTGER4PTGDR | |
| SCHEMBL3214322 | 0.75 | PTGER3 (0.63) | SMN1; SMN2PTGER3PTGER2PTGER4PTGDR | |
| SCHEMBL309761 | 0.75 | PTGER3 (0.63) | SMN1; SMN2PTGER3PTGER2PTGER4PTGDR | |
| SCHEMBL6152820 | 0.75 | KDM4E (0.50) | KDM4EALDH1A1SMN1; SMN2LMNACYP1A2 | |
| SCHEMBL6154507 | 0.73 | HRH1 (0.50) | KDM4EALDH1A1SMN1; SMN2PTGER3PTGER2 | |
| SCHEMBL6154514 | 0.73 | HRH1 (0.50) | KDM4EALDH1A1SMN1; SMN2PTGER3PTGER2 | |
| SCHEMBL3256824 | 0.71 | PTGER3 (0.58) | KDM4EALDH1A1PTGER3PTGER2PTGER4 | |
| SCHEMBL28893816 | 0.71 | PTGER3 (0.58) | KDM4EALDH1A1PTGER3PTGER2PTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1307449-B1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMA (JP) | 2005-12-07 | — | — | EP | disclosed |
| US-6653313-B2 | For treatment and prevention of inflammation, asthma, allergic rhinitis, pain and other disorders | WARNER-LAMBERT COMPANY LLC | 2003-11-25 | — | — | US | disclosed |
| EP-1307449-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2003-05-07 | — | — | EP | disclosed |
| US-20020161006-A1 | 1,4-dihydropyridine compounds as bradykinin antagonists | KAWAMURA MITSUHIRO (US) | 2002-10-31 | — | — | US | disclosed |
| WO-2002012235-A1 | 1,4-DIHYDROPYRIDINES AS BRADYKININ ANTAGONISTS | PFIZER PHARMACEUTICALS INC. (JP) | 2002-02-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161006-A1 | 1,4-dihydropyridine compounds as bradykinin antagonists | BDKRB1, BDKRB2, HRH4 | KDM4E 1330/4885ALDH1A1 1798/4885SMN1; SMN2 4324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.