Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 1/20 | 0.47 |
| ▸ | NOS1 | P29475 | 1/20 | 0.47 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | PTGDR2 | Q9Y5Y4 | 6/20 | 0.37 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.37 |
| ▸ | APEX1 | P27695 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.34 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.34 |
| ▸ | MAP3K5 | Q99683 | 2/20 | 0.33 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.33 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.33 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152398 | 0.89 | NOS3 (0.45) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL6152661 | 0.82 | NOS3 (0.71) | NOS3NOS1NOS2KDM4EALDH1A1 | |
| SCHEMBL6152642 | 0.80 | NOS3 (0.41) | NOS3NOS1NOS2 | |
| SCHEMBL8405425 | 0.80 | NOS3 (0.46) | NOS3NOS1NOS2 | |
| SCHEMBL6153077 | 0.80 | NOS3 (0.46) | NOS3NOS1NOS2PTGDR2KDM4E | |
| SCHEMBL5833910 | 0.79 | NOS3 (0.46) | NOS3NOS1NOS2PTGDR2NR4A1 | |
| SCHEMBL6153072 | 0.76 | NOS3 (0.42) | NOS3NOS1NOS2PTGDR2KDM4E | |
| SCHEMBL6583287 | 0.70 | PDE2A (0.35) | MAP3K5 | |
| SCHEMBL6155624 | 0.69 | NOS3 (0.43) | NOS3NOS1NOS2 | |
| SCHEMBL5833977 | 0.69 | NOS3 (0.44) | NOS3NOS1NOS2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1084109-B1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PROD INC (US) | 2005-01-26 | — | — | EP | disclosed |
| EP-1084109-A1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NITRIC OXIDE SYNTHASE INHIBITORS | Pfizer Products Inc. (US) | 2001-03-21 | — | — | EP | disclosed |
| WO-1999062883-A1 | 2-AMINOPYRIDINES CONTAINING FUSED RING SUBSTITUENTS AS NITRIC OXIDE SYNTHASE INHIBITORS | PFIZER PRODUCTS INC. (US) | 1999-12-09 | — | — | WO | disclosed |