Sugi Predict

Sugi Predict / Compounds / SCHEMBL6583287

SCHEMBL6583287

SCHEMBL6583287

Cc1ccc(C)n1-c1cccc(-c2ccc(O)cc2C2CC2)n1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ PDE2A O00408 3/20 0.35
▸ PDE10A Q9Y233 3/20 0.35
▸ TYR P14679 4/20 0.33
▸ MEN1 O00255 2/20 0.33
▸ POLB P06746 2/20 0.33
▸ GAA P10253 2/20 0.33
▸ KMT2A Q03164 2/20 0.33
▸ NPC1 O15118 1/20 0.33
▸ RAB9A P51151 1/20 0.33
▸ ANPEP P15144 1/20 0.32
▸ DPP4 P27487 1/20 0.32
▸ MAOA P21397 1/20 0.32
▸ MAOB P27338 1/20 0.32
▸ CHRNA7 P36544 1/20 0.31
▸ CCNT1 O60563 1/20 0.31
▸ MAP3K5 Q99683 1/20 0.31
▸ NOTUM Q6P988 1/20 0.31
▸ DYRK1A Q13627 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6583572 0.95 TYR (0.37) PDE2APDE10ATYRMEN1POLB
SCHEMBL6587036 0.95 TYR (0.37) PDE2APDE10ATYRMEN1POLB
SCHEMBL27502446 0.84 PDE2A (0.36) PDE2APDE10ATYRMEN1POLB
SCHEMBL8090303 0.81 MEN1 (0.47) TYRMEN1POLBGAAKMT2A
SCHEMBL6581983 0.79 MEN1 (0.41) MEN1KMT2ANPC1RAB9AMAOA
SCHEMBL6583717 0.77 ANPEP (0.42) PDE2APDE10ATYRMEN1POLB
SCHEMBL6588366 0.77 ESR1 (0.43) MEN1POLBGAAKMT2ARAB9A
SCHEMBL6152642 0.77 NOS3 (0.41) —
SCHEMBL6583994 0.76 NOS3 (0.41) TYRCHRNA7DYRK1A
SCHEMBL6583443 0.75 ALOX5AP (0.41) MEN1KMT2ANPC1RAB9AMAOA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-1523015-A 2-amino-6-(2-substituted-4-phenoxy)-substituted-pyridines �Ʒ� 2004-08-25 — — CN disclosed
CN-1515554-A Intermediate compound for producing 2-amino-6-(2-substituted-4-phenoxy) substituted pyridine compound �Ʒ� 2004-07-28 — — CN disclosed
EP-0958282-B1 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES PFIZER PROD INC (US) 2004-07-21 — — EP disclosed
US-20030162765-A1 Use in treatment and prevention of central nervous system and other disorders PFIZER INC. 2003-08-28 — — US disclosed
US-20010007873-A1 Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... PFIZER INC. 2001-07-12 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010007873-A1 Compounds such as 4-(6-amino-pyridin-2-yl)-3-methoxyphenol as nitric oxide synthase inhibitors used to treat central nervous system disorders, inflammatory disorders, septic shock, etc... NOS1, PTGS1, NOS2 PDE2A 157/4885PDE10A 1142/4885TYR 1395/4885
US-20030162765-A1 Use in treatment and prevention of central nervous system and other disorders GRIN2C, GRIN2A, CNR2 PDE2A 827/4885PDE10A 1271/4885TYR 1571/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.