Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | CFTR | P13569 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.34 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6152278 | 0.89 | ALDH1A1 (0.45) | CFTRMAPTALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL6153355 | 0.85 | — | — | |
| SCHEMBL6152990 | 0.83 | NPC1 (0.33) | CYP2C9GAAMAPTHTTALDH1A1 | |
| SCHEMBL6153162 | 0.83 | ALDH1A1 (0.40) | CYP2C9CFTRMAPTHTTALDH1A1 | |
| SCHEMBL6295391 | 0.80 | CYP2C9 (0.34) | CYP2C9GAAMAPTHTTALDH1A1 | |
| SCHEMBL6152459 | 0.77 | NPC1 (0.49) | CYP2C9GAACFTRMAPTHTT | |
| SCHEMBL6152267 | 0.74 | NPC1 (0.47) | GAAMAPTHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL6152274 | 0.74 | MAPT (0.46) | GAACFTRMAPTHTTALDH1A1 | |
| SCHEMBL6291829 | 0.74 | JAK2 (0.40) | GAAMAPTALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL6152524 | 0.72 | CRHBP (0.41) | GAACFTRMAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1406610-B1 | USE OF SUBSTITUTED GAMMA-LACTONE COMPOUNDS AS MEDICAMENTS | GRUENENTHAL GMBH (DE) | 2005-01-26 | — | — | EP | claimed |