SCHEMBL6153387

SCHEMBL6153387

COc1cccc(C2(CNC(=O)Nc3c(C(C)C)cc(N)cc3C(C)C)CCN(c3ncccc3OCCOc3ccccc3)CC2)c1

nearest known ligand 0.86

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
SOAT1 P35610 10/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6153447 0.95 SOAT1 (0.71) SOAT1
SCHEMBL6153954 0.94 SOAT1 (0.71) SOAT1
SCHEMBL6154191 0.93 SOAT1 (0.70) SOAT1
SCHEMBL6153254 0.93 SOAT1 (0.72) SOAT1
SCHEMBL6152616 0.93 SOAT1 (0.78) SOAT1
SCHEMBL6153328 0.92 SOAT1 (0.71) SOAT1
SCHEMBL6153031 0.89 SOAT1 (0.76) SOAT1
SCHEMBL6153550 0.85 SOAT1 (0.78) SOAT1
SCHEMBL6153561 0.85 SOAT1 (0.61) SOAT1
SCHEMBL6155124 0.84 SOAT1 (1.00) SOAT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20050165057-A1 Novel piperidine derivative DAINIPPON SUMITOMO PHARMA CO., LTD. (JP) 2005-07-28 US disclosed
EP-1500648-A1 NOVEL PIPERIDINE DERIVATIVE SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2005-01-26 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050165057-A1 Novel piperidine derivative ACAT2, ACAT1, LCAT SOAT1 19/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.