Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 7/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | HTT | P42858 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | RRM1 | P23921 | 1/20 | 0.43 |
| ▸ | RRM2 | P31350 | 1/20 | 0.43 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6154622 | 0.77 | SMN1; SMN2 (0.55) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL6153460 | 0.73 | RRM1 (0.56) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL6153416 | 0.71 | KMT2A (0.52) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL6156530 | 0.70 | KMT2A (0.51) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL13569030 | 0.68 | MEN1 (0.61) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL13569001 | 0.67 | NPC1 (0.53) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL7174366 | 0.67 | FURIN (0.54) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL7174364 | 0.67 | FURIN (0.54) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL6667366 | 0.65 | MEN1 (0.47) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 | |
| SCHEMBL12937916 | 0.65 | HDAC8 (0.63) | KMT2ASMN1; SMN2ALDH1A1RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | METABASIS THERAPEUTICS, INC. | 2005-03-24 | — | — | US | disclosed |
| EP-1446110-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | Structural Bioinformatics Inc. (US) | 2004-08-18 | — | — | EP | disclosed |
| WO-2003032916-A2 | ORGANOSULFUR INHIBITORS OF TYROSINE PHOSPHATASES | STRUCTURAL BIOINFORMATICS INC. (US) | 2003-04-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050065118-A1 | Organosulfur inhibitors of tyrosine phosphatases | PTPRS, PTPRJ, PTPRCAP | KMT2A 875/4885SMN1; SMN2 2211/4885ALDH1A1 961/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.